| T O P I C R E V I E W |
| John Stone |
Posted - 01/27/2009 : 07:26:21
http://pediatrics.aappublications.org/cgi/content/abstract/123/2/475
Neuropsychological Performance 10 Years After Immunization in Infancy With Thimerosal-Containing Vaccines
Alberto Eugenio Tozzi, MDa, Patrizia Bisiacchi, PhDb, Vincenza Tarantino, PhDb, Barbara De Mei, DSociolc, Lidia D'Elia, DPsycholc, Flavia Chiarotti, DStatc and Stefania Salmaso, DBiolc
OBJECTIVE. Thimerosal, a mercury compound used as a preservative in vaccines administered during infancy, has been suspected to affect neuropsychological development. We compared the neuropsychological performance, 10 years after vaccination, of 2 groups of children exposed randomly to different amounts of thimerosal through immunization.
METHODS. Children who were enrolled in an efficacy trial of pertussis vaccines in 1992–1993 were contacted in 2003. Two groups of children were identified, according to thimerosal content in vaccines assigned randomly in the first year of life (cumulative ethylmercury intake of 62.5 or 137.5 µg), and were compared with respect to neuropsychological outcomes. Eleven standardized neuropsychological tests, for a total of 24 outcomes, were administered to children during school hours. Mean scores of neuropsychological tests in the domains of memory and learning, attention, executive functions, visuospatial functions, language, and motor skills were compared according to thimerosal exposure and gender. Standard regression coefficients obtained through multivariate linear regression analyses were used as a measure of effect.
RESULTS. Nearly 70% of the invited subjects participated in the neuropsychological assessment (N = 1403). Among the 24 neuropsychological outcomes that were evaluated, only 2 were significantly associated with thimerosal exposure. Girls with higher thimerosal intake had lower mean scores in the finger-tapping test with the dominant hand and in the Boston Naming Test.
CONCLUSIONS. Given the large number of statistical comparisons performed, the few associations found between thimerosal exposure and neuropsychological development might be attributable to chance. The associations found, although statistically significant, were based on small differences in mean test scores, and their clinical relevance remains to be determined.
However, from the main text:
'Some limitations should be considered in the interpretation of our results. The cumulative intake of thimerosal was relatively low, compared with that in other countries including the United States, where vaccination schedules included more thimerosal-containing vaccines in the first year of life. Moreover, there was no comparison group with no exposure to thimerosal, although our setting was appropriate to identify a dose response effect in the absence of any evidence suggesting a threshold dose for observation of an effect. Our analysis included only healthy children who were selected during enrollment in the original trial, and some families might have declined to participate in the present study because their children had cognitive developmental problems. This might have reduced the prevalence of adverse neuropsychological conditions and might have made potential differences hard to detect. The eligibility criteria of the original trial also limited the participation of low birth weight children, and only 55 children with birth weights of <2500 g underwent the neuropsychological evaluation (data not shown). Moreover, only 1% of children in this study received hepatitis B virus vaccine at birth. Although no effect of birth weight according to thimerosal intake was detected through multivariate analyses, our study was not powered to detect an association of thimerosal exposure and neuropsychological development in low birth weight infants.'
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| 15 L A T E S T R E P L I E S (Newest First) |
| John Stone |
Posted - 01/30/2009 : 08:15:54
Just to confirm that I wrote to Associate Press pointing out the deception (twice) and have received no response. |
| justsayno |
Posted - 01/30/2009 : 08:04:08
Forbalance wrote:
"What the study proves, John, is that there is no relationship between the dose of thiomersal and neurodevelopment disorders; it's also worth pointing out that one only case of autism was diagnosed in the entire study! For anyone supporting the thiomersal-autism theory, this study should surely make them pause for thought."
Aye right. Yet another study where the so called scientists don't actually study the affected children. This study proves only four things -
1 - how not to conduct a scientific study into the neurological effects of an environmental toxin. (It would help if the sample included some autistic children who had been exposed to the same level of thimerisol as USA/UK kids, and if the control were unvaccinated). Why after 18 years since the autism explosion began has there not been one study which compares vaccinated with unvaccinated? Something to hide?
2 - that individuals within the CDC are guilty of perpetuating the mercury cover-up they initiated at Simpsonwood.
3 - said individuals are getting increasingly desperate in their search for 'science' which refutes the mercury theory.
4 - individuals within Associated Press are either as thick as mince to fall for this CDC funded garbage and spin, and/or they are complicit in the Simpsonwood conspiracy. |
| Govna |
Posted - 01/29/2009 : 16:00:33
quote:
[i]Originally posted by forbalance[/i]
[br] it's also worth pointing out that one only case of autism was diagnosed in the entire study!
And thus the study is clearly worthless.
The flaws in the approach are so fundamental it is only worthy of discussion by secondary school children studying statistics as an example of what to avoid. |
| Govna |
Posted - 01/29/2009 : 15:49:58
Thanks, John and John. Bed time reading for a good few nights there. |
| John Stone |
Posted - 01/29/2009 : 13:49:09
Hi Francesco,
I remember you well - and by the way your English is just great. I also saw your letter in Age of Autism yesterday and wanted to email you, but couldn't locate your address. Good to hear from you.
John
PS Could you email me at JohnDanStone@gmail.com |
| francesco64 |
Posted - 01/29/2009 : 10:57:54
I'm Italian, my english is very poor, but I hope you will understand me.
My son was vaccinated (in postmarketing phase) with the thimerosal containing vaccine of the mentioned pertussis clinical trial in the '90, and now he suffers from an autistic disorder.
Just a comment on this study:
- The authors have indicated they have no financial relationships relevant to this article to disclose.
Tozzi, that now is working at Bambin Gesù Hospital, in the '90 worked at Istituto Superiore di Sanità, with Stefania Salmaso (another author of the Pediatric's publication).
Both were member of 'Progetto Pertosse Working Group', the working group of the mentioned DTaP clinical trial: they administered (not materially) the vaccines more than ten years ago. And to do that have received funds from US NIAID and from vaccine manufacturers, and now they have received funds from CDC.
Today should tell us that the vaccines were not safe?
Ciao a tutti!
Francesco
P.S. to John Stone: do you remember me?
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| GUS THE FUSS |
Posted - 01/29/2009 : 09:15:50
Maybe wayofbalnce and sinking fast could tell us what the new safe dose of mercury is.Going by the shots given in the study its several times over the recommended "safe"dose” of the second most toxic substance known to man(not trolls)supported by the GSK governments around the world.
MMR RIP
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| John Stone |
Posted - 01/29/2009 : 08:58:43
I could not put it better than the poster Doybia in the Robert Kennedy/David Kirby blog n Huffington Post:
"The best way to un-confuse these parents would be for the CDC to actually do a study of the sick children and figure out what happened. Instead of studying healthy kids in Italy they could study sick kids in the U.S. What a concept!"
http://www.huffingtonpost.com/robert-f-kennedy-jr-and-david-kirby/autism-vaccines-and-the-c_b_161395.html
I can't see why you would expect to see a curve at all when all the confounders have been taken into account - you surgically remove all the difficult cases and then you expect to see an effect. Only in the world of pharma CDC doublethink, and Bad Science trolls.
quote:
[i]Originally posted by forbalance[/i]
[br]"Tozzi, himself, concedes that exposure is not comparable to the US, they didn't do Hep B at birth, sick and low weight babies were pre-excluded by the earlier trial and there was a >30% drop out rate for the tests."
Regardless, you have to accept the fact that you should still see a dose response curve with the differing levels of thiomersal injected.
"Most importantly, as Tozzi also concedes, parents with disabled children might have been less likely to volunteer their children, and (I don't think this is speculation) the more disabled they were the less likely they would be to be volunteered (most ASD children will not get near it - even if they had the conceptual skill to understand the tests, you would not expose them to the stress). The "limitations" are not marginal but actually offer a complete explanation of why there are almost no cases."
Might, maybe, perhaps. Either way, the study is a hefty blow to anyone claiming thiomersal has any hand in autism incidence.
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| john |
Posted - 01/29/2009 : 08:22:31
Did someone mention the Danish study---you can see it shredded http://whale.to/a/danish.html
another one for the shredder I see.
this bunch of sheisters don't give up easily
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| forbalance |
Posted - 01/29/2009 : 08:03:18
"Tozzi, himself, concedes that exposure is not comparable to the US, they didn't do Hep B at birth, sick and low weight babies were pre-excluded by the earlier trial and there was a >30% drop out rate for the tests."
Regardless, you have to accept the fact that you should still see a dose response curve with the differing levels of thiomersal injected.
"Most importantly, as Tozzi also concedes, parents with disabled children might have been less likely to volunteer their children, and (I don't think this is speculation) the more disabled they were the less likely they would be to be volunteered (most ASD children will not get near it - even if they had the conceptual skill to understand the tests, you would not expose them to the stress). The "limitations" are not marginal but actually offer a complete explanation of why there are almost no cases."
Might, maybe, perhaps. Either way, the study is a hefty blow to anyone claiming thiomersal has any hand in autism incidence. |
| John Stone |
Posted - 01/29/2009 : 07:19:01
Govna
I can't imagine why Aasa was so unhelpful:
http://www.jpands.org/vol9no3/goldman.pdf
http://www.jpands.org/vol9no3/stott.pdf
but bear in mind that they are also corroborated by by the Cochrane review of MMR 2005:
"The interpretation of the study by Madsen was made difficult by the unequal length of follow up for younger cohort members as well as the use of the date of diagnosis rather than onset of symptoms of autism".
What they don't tell you openly was that the younger cohort members were the MMR vaccinated group, thus there was under-ascertainment for autism diagnosis as against controls.
http://mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD004407/frame.html
quote:
[i]Originally posted by Govna[/i]
[br]Is anyone able to post a link to a similar discussion of the oft quoted Danish study on the vaccine-autism link?
I still have a lot of catching up to do on this particular topic.
Thanks.
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| Aasa |
Posted - 01/29/2009 : 04:42:21
If you're looking for a link to the "oft-quoted" Danish study, and you are asking US, go do your homework elsewhere, and return when you have something to contribute, ye lazy sloth~!!
I don't usually get nasty with posters, but lately the lay of the land seems to have changed somewhat!!
Aasa
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| Govna |
Posted - 01/29/2009 : 02:52:03
Is anyone able to post a link to a similar discussion of the oft quoted Danish study on the vaccine-autism link?
I still have a lot of catching up to do on this particular topic.
Thanks. |
| John Stone |
Posted - 01/28/2009 : 23:58:06
New article
http://childhealthsafety.wordpress.com/2009/01/28/cdc-fraud-tax-dollars-and-italian-vaccine-mercury-study/ |
| John Stone |
Posted - 01/28/2009 : 12:10:44
Forbalance
You obviously can't read. In favour of this study is that it is actually written in plain English.
Tozzi, himself, concedes that exposure is not comparable to the US, they didn't do Hep B at birth, sick and low weight babies were pre-excluded by the earlier trial and there was a >30% drop out rate for the tests. Most importantly, as Tozzi also concedes, parents with disabled children might have been less likely to volunteer their children, and (I don't think this is speculation) the more disabled they were the less likely they would be to be volunteered (most ASD children will not get near it - even if they had the conceptual skill to understand the tests, you would not expose them to the stress). The "limitations" are not marginal but actually offer a complete explanation of why there are almost no cases.
But to talk about "proof" is also in relation to this kind of study scientifically illiterate. All they are saying is their findings corroborate other negative findings, but it is a classic example of a study designed to detect nothing. It is frankly a joke: after ten years of time wasting the emperor has no clothes.
quote:
[i]Originally posted by forbalance[/i]
[br]What the study proves, John, is that there is no relationship between the dose of thiomersal and neurodevelopment disorders; it's also worth pointing out that one only case of autism was diagnosed in the entire study! For anyone supporting the thiomersal-autism theory, this study should surely make them pause for thought.
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