| Author |
 Topic  |
|
thomas p
United Kingdom
314 Posts |
 Posted - 09/04/2008 : 12:56:19
|
Published today in PLoS one is a study replicating Wakefields '98 Lancet study, only this time done on a larger group and more thoroughly. the full article is available completely free of charge here:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003140#top
I thought that I'd share with you the full text of the Conclusions/Significance part of the abstractquote:
This study provides strong evidence against association of autism with persistent MV [Measles Virus - thomas] RNA in the GI tract or MMR exposure. Autism with GI disturbances is associated with elevated rates of regression in language or other skills and may represent an endophenotype distinct from other ASD.
|
|
|
Cybertiger
United Kingdom
976 Posts |
Posted - 09/04/2008 : 13:33:47
|
| Quack, quack. This is Donald Duck science ... |
 |
|
|
jabsadmin
958 Posts |
Posted - 09/04/2008 : 14:23:32
|
http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=109&STORY=/www/story/09-03-2008/0004878438&EDATE=
CDC Misses Target With Flawed MMR/Autism Study
NAA says: Wrong Question Asked. Wrong Children Studied. Wrong
Conclusions Reached.
NIXA, Mo., Sept. 3 /PRNewswire-USNewswire/ -- A Centers for Disease Control and Prevention (CDC) study released today claims there is no link between the MMR vaccine and autism. The National Autism Association (NAA) says this study does nothing to dispel the growing public concern over a vaccine-autism connection and raises several questions concerning design and methodology.
For years, parents have claimed that MMR triggered their child's
subsequent GI (gastrointestinal) disease and autism. In a 2002 paper where the majority of autistic children were found to have measles in their intestines, the children examined showed a clear temporal link between MMR exposure and regression. The CDC's attempt to replicate the 2002 study fell far short of proving the safety of the MMR vaccine.
1. The CDC study was designed to detect persistent measles virus in autistic children with GI problems. The assumption being if there is no measles virus at the long delayed time of biopsy, there is no link between autism and MMR. But NAA says this underlying assumption is wrong. The questions should have been: Do normally developing children meeting all milestones have an MMR shot, develop GI problems and then regress into autism? Do they have evidence of measles and disease in their colons compared to non-vaccinated age and sex matched controls?
2. In the current CDC study, only a small subgroup of children was the correct phenotype to study. From page 7, "Only 5 of 25 subjects (20%) had received MMR before the onset of GI complaints and had also had onset of GI episodes before the onset of AUT (P=0.03)." The other 20 autistic children in the study had GI problems but the pathology developed before the MMR vaccine. Additionally, the controls all received the MMR vaccine and had
gastrointestinal symptoms. The controls should have been free of exposure to vaccine measles in order to make a comparison relevant for purposes of causation.
3. Inflammatory bowel disease in the absence of MMR RNA does not mean that MMR shot didn't precipitate the GI disease and didn't precipitate autism. A similar example would be rheumatic fever where the infection is cleared quickly but damage to the heart and/or brain last a lifetime.
Public confidence in the safety of vaccines is at risk until safety studies are performed that are required by law, ethics, and science. NAA calls for a vaccinated vs. non-vaccinated study comparing all health outcomes including autism. The CDC is in charge of vaccine safety, owns patents to vaccines (according to a UPI Investigative Report from 2003) and is in charge of promoting vaccines. The public should demand that vaccine safety be taken away from an agency with such conflicts and support HR#1973, the Vaccine Safety and Public Confidence Assurance Act."
For more information, visit http://www.nationalautism.org.
Contacts:
Wendy Fournier (Portsmouth, RI) 401-835-5828
Rita Shreffler (Nixa, MO) 401-632-6452
SOURCE National Autism Association
--------------------------------------------------------------------------------
|
|
|
|
whatif
USA
286 Posts |
Posted - 09/04/2008 : 15:35:10
|
quote:
[i]Originally posted by Cybertiger[/i]
[br]Quack, quack. This is Donald Duck science ...
WATT about Daisy Duck? |
|
|
|
John Stone
United Kingdom
1253 Posts |
Posted - 09/04/2008 : 18:28:12
|
What is fascinating about this episode is the UK media blackout. Apart from providing at best weak evidence it (1) supports the ethicality of the Royal Free clinical investigations (2) endorses the validity of results from the O'Leary lab.
The dog that didn't bak in the night, eh? |
|
|
|
Cybertiger
United Kingdom
976 Posts |
|
|
John Stone
United Kingdom
1253 Posts |
Posted - 09/04/2008 : 21:03:32
|
| What a pathetic bunch - they really can't read it, but the bigshots know it has only delivered a paradox. How do they explain the persecution of the Royal Free doctors, and how do they trash O'Leary one minute and call on him for salvation the next. Oh dear, oh dear, oh dear. |
|
|
|
GUS THE FUSS
United Kingdom
1440 Posts |
Posted - 09/04/2008 : 21:07:07
|
More like oh deer! oh deer !oh deer !
Would explain all baseless journalism
MMR RIP
|
Edited by - GUS THE FUSS on 09/04/2008 21:09:28 |
|
|
|
John Stone
United Kingdom
1253 Posts |
Posted - 09/04/2008 : 21:18:41
|
Gus
As you say it reflects particularly on Deer and his mate Evan Harris. |
Edited by - John Stone on 09/04/2008 22:32:00 |
|
|
|
Rosemary
United Kingdom
1969 Posts |
Posted - 09/04/2008 : 22:51:25
|
SafeMinds Statement on Measles Virus and Autism Study
<http://rs6.net/tn.jsp?e=001PdO608L7qnze6m2PGJpaphcqUYCR8Xen4MxbnPwxc-wCRtTNQxWvZRvRD4wtWTKYt1wA2azKHdyeheVOGu4iJbwbmwY0SMEtr78rvFSoklLjyAgF7EJpQZj6F2YuMzmQy-1zOx6Rrylrfblnh_PGNA= =>
A scientific study released today examined the hypothesis that measles virus persisting in the intestinal tract from the MMR vaccine causes or exacerbates autism. The study refuted this hypothesis for the majority of autism cases while validating the link between gastrointestinal (GI) disease, inflammation and autistic regression. The study design precluded assessment of a role for acute measles infection from MMR in a subset of children with autism and did not examine the role of other vaccines, vaccine components such as thimerosal, or other environmental exposures which can trigger gastrointestinal and immunological problems. The topic is of public health interest due to the increasing autism epidemic and parent and scientific reports connecting mercury and vaccines, including MMR, with autism onset.
The study, "Lack of an association between measles virus vaccine and autism with enteropathy: a case-control study" by Mady Hornig and colleagues, appears in this month's PloS One journal. Colon biopsies from 38 children presenting with gastrointestinal disorder, 25 with autism and 13 without neurological differences, were examined for presence of measles virus RNA by three laboratories to ensure validity. All children had been given the MMR vaccine when younger, and except for one subject, the vaccine was given more than 6 months prior to the biopsy, in order to determine persistence. The MMR is a live virus vaccine and failure to clear the attenuated measles virus is a known but rare occurrence after vaccination.
The persistent measles and autism hypothesis, linking bowel disease, autistic regression and MMR, was originally made by Andrew Wakefield and colleagues in 1998. One of the three labs involved in the Hornig study was led by John O'Leary who conducted the testing for the
Wakefield study. The three Hornig study labs validated each other, confirming the rigorousness of Dr. O'Leary's work. Dr. O'Leary
conducted the testing for one of the autism test cases now in the Federal Court for Vaccine Claims. The child, who regressed into autism and bowel disease after receiving the MMR, tested positive for measles virus. The Hornig study also substantiates the
link between autistic regression and gastrointestinal disorder.
The Hornig study found only one autism patient with persistent measles virus. None was detected in the remaining 24 children. This finding differs from the Wakefield and more recent studies which reported a high percentage of children with regressive autism and bowel disease with detectable measles virus. The discrepancy
was not explained but may be due to how and when the biopsies were taken or differences in the study samples.
The Hornig findings suggest that persistence may not be a factor but inadequately address whether measles vaccination may lead to an acute reaction that contributes to dysfunction. An acute or 'hit and run' mechanism means that the initial effect occurs and the virus is rapidly cleared. The effect would not require persistence and is how
many biological disturbances arise from pathogens and toxins. The study sample was small, making characterization of subgroups difficult. Autism is considered a complex and heterogeneous disorder with multiple, interacting causal and exacerbating factors. The MMR vaccine may have led to dysfunction in a subset of children and other triggers may underlie other cases. While half the autism cases in the study had gastrointestinal or autism symptoms prior to
receipt of the MMR, additional triggers such as other vaccines or environmental pollutants acting on the majority of cases would effectively wash out a positive MMR-autism association in a subset.
Larger studies are needed to tease out the role of the various contributors to autism onset and severity of symptoms, including GI problems. These studies need to examine multiple factors, not just one. In particular, a comparison of health outcomes in vaccinated and unvaccinated populations is warranted. The Hornig study has
advanced our understanding of gastrointestinal inflammation and autism and casts doubt on measles persistence in most children with autism, but it does not rule out an acute MMR effect in a subset and does not absolve multiple vaccinations or mercury from playing a role in autism.
<http://rs6.net/tn.jsp?e=001PdO608L7qnwEuBF0phS65Cinbi4MmaQCe5KxCw5twj9jE7taMbjH9oM-anm5czs_5R7e4s3BUdzZU3DW6TFWhSa9D2Oo81mQRB6mAbhu4eXauqcqA0icSYcdMgnzIyEnZTFp4t9tU9ZTBALIwQmsoDaKKR4sAObch3xexIlLds8=>
Click here to read National Autism Association statement on study.
|
|
|
|
Rosemary
United Kingdom
1969 Posts |
Posted - 09/04/2008 : 23:20:47
|
http://www.thoughtfulhouse.org/pr/040908.htm
Press Release
For Immediate Release:
September 4, 2008
Autism Researchers Comment on New Study and Welcome the Affirmation of Previous Measles Findings
A study published yesterday in the Public Library of Science One (PLOS1), an on-line journal, failed to find evidence of measles virus in the intestinal tissue of 24 children with autistic regression and gastrointestinal symptoms. The findings contrast with those published in 2002 in which researchers from Ireland and the UK found measles in 75 of 91 biopsies from autistic children with GI inflammation, and in only 5 of 70 samples from non-autistic children(1). The children with autism in the 2002 study developed gastrointestinal symptoms and autistic regression after the MMR vaccine.
In the study published yesterday, conducted by three independent laboratories, only 5 of the 25 children developed these symptoms after the MMR vaccine and therefore, only these five are comparable to the 2002 study. This new study confirmed that results from the laboratory of Professor John O’Leary (one of the collaborators on the new study, and senior author of the 2002 study) were correct, and identical to the results obtained by the laboratories of the Centers for Disease Control and Prevention (CDC) and Dr. Ian Lipkin of Columbia University.
In that this new study affirms the reliability of Professor O’Leary’s laboratory and therefore of his previous findings, a major impact upon the current hearings in vaccine court is likely, wherein the government’s defense relies largely on the claim that Professor O’Leary’s finding of measles in the intestinal biopsy of Michelle Cedillo (a child with severe autism and epilepsy) was unreliable. The historical reliability of the measles assay used in Professor O’Leary’s laboratory is now confirmed.
The authors of the PLOS1 study make the erroneous claim that epidemiological studies have not supported an MMR-autism link, when in fact the CDC’s own study published in 2004 shows a significant association between autism and younger age at the time of MMR vaccination.(2)
We are pleased to see that this new study provides further confirmation that children with autism suffer from gastrointestinal problems that deserve to be addressed as a priority.
Dr. Andrew Wakefield, Executive Director of Thoughtful House Center for Children, whose work has focused on intestinal disease, and on the possible role of MMR vaccine in regressive autism in children with GI symptoms, welcomed these new findings. Dr. Wakefield was a co-author of the 2002 paper that, unlike yesterday’s study, examined children in the majority of whom there was a clear temporal link between MMR exposure and regression. Dr. Wakefield comments, “The search for the ‘footprints’ of measles virus in the intestine is merited, based upon the previous findings and the intestinal disease that is commonly found in these children. This new study rules out only one possibility – that the measles virus must remain for the long term in the intestine. We need to consider that the MMR vaccine can cause autism as a hit-and-run injury, but not necessarily leave the measles virus behind.”
While we welcome this study as a piece in the ever-growing body of evidence that illuminates the complexity of autism and the possible factors that cause it, it is clear that yesterday’s study does not establish that the MMR vaccine is not associated with autism. This work examines one small part of a very complex equation, and in fact by affirming Professor O’Leary’s laboratory and assay methods, it inadvertently endorses the validity of his 2002 findings of vaccine-strain measles virus in the gut tissue of a group of children with autism.
References:
Uhlmann V., Martin C, Shiels, Wakefield AJ, O.Leary JJ. Possible viral pathogenesis of a novel paediatric inflammatory bowel disease. Molecular Pathology 2002;55:84-90
DeStefano F, Bhasin TK, Thompson WW, Yeargin-Allsopp M, Boyle C. Age at first measles-mumps-rubella vaccination in children with autism and school-matched control subjects: a population-based study in metropolitan Atlanta. Pediatrics 2004, 113:259–266.
|
Edited by - Rosemary on 09/04/2008 23:23:48 |
|
|
|
Cybertiger
United Kingdom
976 Posts |
|
|
John Stone
United Kingdom
1253 Posts |
Posted - 09/05/2008 : 14:13:56
|
Jerkery, indeed.
I was present for one morning at the GMC on which Wakefield gave evidence. Wakefield, himself, had no imput into ethical decisions which were taken in relation to individual patients by John Walker-Smith and Simon Murch in consultation with other doctors in the hospital and at Great Ormond Street.
And you wonder why Brian Deer has been silent all this time!
quote:
[i]Originally posted by Cybertiger[/i]
[br]Give me strength! Give him the gold medal for jerkery. TeeHee really is the prize jerk of all jerks!
Just read this fatuous post on the CoxAR thread on the 'rancidscience' forum.
http://www.badscience.net/forum/viewtopic.php?f=3&t=6065&st=0&sk=t&sd=a&start=15#p108153
|
|
|
|
whatif
USA
286 Posts |
Posted - 09/05/2008 : 15:09:42
|
quote:
[i]Originally posted by Cybertiger[/i]
[br]Give me strength! Give him the gold medal for jerkery. TeeHee really is the prize jerk of all jerks!
Just read this fatuous post on the CoxAR thread on the 'rancidscience' forum.
http://www.badscience.net/forum/viewtopic.php?f=3&t=6065&st=0&sk=t&sd=a&start=15#p108153
Let's see if I've got this one straight. One of the mail runners of 'rancidscience' now thinks it aight to perform a colonoscopy but not a lumbar puncture. Let's try and work it out:
1) GI symptoms/signs/complications = colonoscopy ok
2) CNS symptoms/signs/complications = lumbar puncture sadistic and not ok
Yup, makes perfect sense to me! Well only because it's coming from one of the puffacre puffingtons. Ah hell, I'm confused, maybe the 'rancidscience' part is what makes the most sense. Or, maybe this is why the sentence before the previous one makes sense. Help. |
Edited by - whatif on 09/05/2008 15:47:01 |
|
|
|
John Stone
United Kingdom
1253 Posts |
Posted - 09/05/2008 : 15:27:39
|
Whatif
That's right - actually they don't seem to understand that the GMC have been prosecuting the doctors for the colonoscopies and not just the lumbar punctures. Anyone who read Martin Walker's account would know that the prosecution have been trying to argue that the patients were free of gut symptoms, and were being gratuitously tortured by the GI department of the Royal Free.
quote:
[i]Originally posted by whatif[/i]
[br]quote:
[i]Originally posted by Cybertiger[/i]
[br]Give me strength! Give him the gold medal for jerkery. TeeHee really is the prize jerk of all jerks!
Just read this fatuous post on the CoxAR thread on the 'rancidscience' forum.
http://www.badscience.net/forum/viewtopic.php?f=3&t=6065&st=0&sk=t&sd=a&start=15#p108153
Let's see if I've got this one straight. One of the mail runners of 'rancidscience' now thinks it aight to perform a colonoscopoy but not a lumbar puncture. Let's try and work it out:
1) GI symptoms/complications = colonscopy ok
2) CNS symptoms/complications = lumbar puncture sadistic and not ok
Yup, makes perfect sense to me! Well only because it's coming from one of the puffacre puffingtons. Ah hell, I'm confused, maybe the 'rancidscience' part is what makes the most sense. Or, maybe this is why the sentence before last makes sense. Help.
|
|
|
|
justsayno
United Kingdom
130 Posts |
Posted - 09/05/2008 : 18:52:29
|
This issue reminds me of a documentary broadcast on BBC Scotland about 10 years ago about Ninewells Hospital in Dundee (it was very similar to ITV's "Jimmy's" series about St James in Leeds?). Anyway, iirc one of the cases they briefly followed was that of a toddler who had been brought in by his mother, as he was continually screaming in pain. I specifically remember the mother asking a nurse if it could have been the MMR which he had had just recently and the nurse immediately stating that there could be no connection. But I am sure that as none of the tests had identified any possible cause for the pain the consultants were going to perform a lumbar puncture.
edited for typo |
Edited by - justsayno on 09/05/2008 19:01:43 |
|
|
|
Topic |
|
|
|
How Andrew Wakefield should have done it
